(2014). establishment and characterization of a microfluidically supported in vitro organoid model of the Central institutions and faculties of Jena University. Institute of Biochemistry IIUniversity Hospital JenaNonnenplan 2-407743 JenaPhone: +49 3641 9 390 910Fax:      +49 3641 9 396 402alexander.mosig@med.uni-jena.deHomepage. A. Mosig, Algorithmen und Datenstrukturen zur effizienten Konstellationssuche (in German, Algorithms and data structures for efficient constellation searching), Master's thesis, Univ. Here, we... Background Angiotensin‐converting enzyme (ACE) plays a major role in blood pressure regulation and cardiovascular homeostasis. Using mass spectrometry, we identified a C-terminal fragment of alpha-1-antitrypsin, designated CAAP48, as a new sepsis biomarker that actively participates in the pathophysiology... We present a novel open-source modular electro-optical toolbox to be used for many different optical setups. Liposomes represent suitable tools for the diagnosis and treatment of a variety of diseases, including cancers. Increased CD36 and CD91/Lrp1 levels on the surface of monocytes from FH patients and their role in LDL uptake. Friedrich Schiller University, Institute of Microbiology. 3, Room 4.150, 4th floor Phone: +49 (0) 3641 / 9-43160 Fax: +49 (0) 3641 / 9-43163 G.Steinborn@wiwi.uni-jena.de Electronic address: Alexander.MOSIG@med.uni-jena.de. (1) Background: Epithelial ovarian cancer (EOC) is the most lethal cancer of the female reproductive system. The liver is a central organ in the metabolization of nutrition, endogenous and exogenous substances, and xenobiotic drugs. Nevertheless, Jena's outstanding competence in high-frequency engineering paved the way to laser technology and, thus, the rise of optics and photonics to one of the most important fields of research at the Friedrich Schiller University Jena. Was aber sind Organ-on-a-Chip-Systeme und wo liegt ihre Anwendung? We show that FKN triggers different effects in CD16(+) and CD16(-) monocytes, the two major subsets of human monocytes. To analyze, if circulating monocytes already show increased lipid content and differences in lipoprotein metabolism, we compared monocytes from patients with Familial Hypercholesterolemia (FH) with th... Serum oxLDL levels and neutral lipid content of monocytes from FH patients and healthy individuals. Image: Jan-Peter Kasper (University of Jena) The Abbe Center of Photonics (ACP) hosts fundamental and applied research in optics and photonics. Search for more papers by this author. (2008). The intestine is the primary reservoir of Candida albicans that can cause systemic infections in immunocompromised patients. Preparation, modification and characterization of polymeric nanoparticles for targeted drug delivery applications Jena University Hospital Center for Sepsis Control and Care Dr. Alexander Mosig, Email: alexander.mosig[at]med.uni-jena.de, Phone +49 03641-9346418 References 1. The current in vitro gut models that... Alterations of the microbial composition in the gut and the concomitant dysregulation of the mucosal immune response are associated with the pathogenesis of opportunistic infections, chronic inflammation, and inflammatory bowel disease. Besides viruses, bacterial co-infections dramatically exacerbate infection. Alexander S. Mosig1,2 1Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany 2Institute of Biochemistry II, Jena University Hospital, Jena, Germany 3fzmbResearchCentreofMedical Technology and Biotechnology, Bad Langensalza, Germany 4Arthrospec GmbH, Erfurt, Germany Research Article Novel approach for the prediction of cell Service we provide. 07743 Jena Site plan +49 3641 9-48831 +49 3641 9-48832 geographie@uni-jena.de Opening hours: Mo und Do 13-14 Uhr Di und Mi 10-12 Uhr Postal address: Institut für Geographie Löbdergraben 32 07743 Jena Share this page. In this reservoir, the fungus exists as a harmless commensal. 10.4155/fsoa-2016-0038 Future Sci. In the present study, mitochondrial staining applying a novel dye, V07-07059, was performed in human embryonic kidney cells, a human vascular endothelial cell line and primary human mononuclear cells. We will see you in Jena in the winter semester 2020/21—partly on site, partly online 10 July 2010 10 July 2010 Educational operations of the winter semester 2020/21 at the Friedrich Schiller University will start on 2 November 2020 and will be conducted—at least partially—on site. Due to our privacy policy, only current members can send messages to people on ResearchGate. sebastiano.bernuzzi[AT]uni-jena.de Theoretisch-Physikalisches Institut Friedrich-Schiller-Universitaet Jena Max Wien Platz 1 D-07743 Jena, Germany Office 209. For postdocs and staff, there … Identifikation von Hochfettdiät-induzierten inflammatorischen Gennetzwerken assoziiert mit der Suppression anti-inflammatorischer Phospholipide in humanem Fettgewebe in der NUGAT (NutriGenomics Analysis in Twins) Studie, Sensor enhanced microfluidic devices for cell based assays and organs on chip. Portrait and overview. human liver sinusoid. Raasch M, Rennert K, Jahn T, Peters S, Henkel T, Huber O, Schulz I, et al. The liver organoid is composed of vascular and hepatocyte cell layers integrating It cross-links the activities of its principal and visiting scientists together with around 300 doctoral and more than 150 Master's degree students. The memberships of Friedrich Schiller University Jena. However, only few studies exist so far regarding their suitability to detect the effects of drugs requiring a preceding activation via the cytochrome P450 (CYP) system. University of Jena de; de; Institute Departments Research Studies Homepage Institute Departments Research Studies Welcome to the Institute of Sociology. Harvesting cultivated macrophages for tissue engineering purposes by enzymatic digestion of cell adhesion molecules can potentially result in unintended activation, altered function, or behavior of these cells. CAT12 Toolbox (for SPM12) Download the newest version from that Folder.. unpack the zip-file; remove the old cat12 folder; copy or link the cat12 folder to the spm12/toolbox directory Chemisch-Geowissenschaftliche Fakultät der Universität Jena, Unter dem Dach der Chemisch-Geowissenschaftlichen Fakultät sind an der Friedrich-Schiller Universität Jena die Fachrichtungen Chemie, Geologie, Mineralogie, Geophysik und Geographie vereint. E‐mail: sandy.mosig@mti.uni‐jena.de Search for more papers by this author Francisella tularensis, a gram-negative bacterium replicates intracellularly within macrophages and efficiently evades the innate immune response. The aim was to detect the motion processes and adsorption processes of cells and particles in the simulation of flow conditions completely and more precisely. 12 Institute of Biochemistry II, Jena University Hospital, 07743 Jena, Germany; Center for Sepsis Control and Care, Jena University Hospital, 07747 Jena, Germany. (2014). jena.de/Karriere or write an Email to alexander.mosig@med.uni-jena.de Reference number: DM23/2020 (internal and external) Application deadline: 30. We t... White blood cells (WBCs) express tens of thousands of genes, whose expression levels are modified by genetic and external factors. Gianni Panagiotou. FASEB J.. Mosig. Office: Carl-Zeiss-Str. April 2020 In case of equal qualification, persons with disabilities will be given priority. The fluorescent dye, even when coupled to a nanoparticle, mimics... For many problems in system biology or pharmacology, in-vivo-like models of cell-cell interactions or organ functions are highly sought after. Image: Jan-Peter Kasper (University of Jena) Lichtwerkstatt - Open Photonics Makerspace. The Molecular Photonics group is a team of chemists and physicists passionate about studying the properties of dynamic structural and electronic changes of molecules, supra- and macromolecular structures as well as molecularly functionalized interfaces. Since obesity is triggered by energy dense diets, we hypothesized that nutrient induced intestinal hormones such as glucose-dependent insulinotropic peptide (GIP) may directly st... Hemodynamic forces generated by the blood floware of central importance for the function of endothelial cells (ECs),which form a biologically active cellular monolayer in blood vessels and serve as a selective barrier for molecular permeability. 30 Sep 2020. It has been suggested that taurolidine has no severe side-effects, but after long-term use morphological and functional changes of the liver were reported. Petra joined Jena University Hospital (JUH), Department of Anaesthesiology and Intensive Care Medicine, in November 2016 as senior academic clinical lecturer to connect her research interests and expertise with the infection research at JUH and its integrated research and treatment Centre for Sepsis Control and Care (CSCC). OA (2016) 3(2), FSO130 future science grou Editorial Mosig fluidic devices for … sandy.mosig@mti.uni‐jena.de; Molecular Hemostaseology, Friedrich‐Schiller‐University of Jena, Jena, Germany. Since 2015 Elected member of the Board of Directors of the CSCC. Institute of Forensic Medicine, Jena University Hospital, 07747 Jena, Germany. T lymphocytes get in contact with affected organs (e.g., lung) or cells (e.g., erythrocytes), as well as with smoke components and bioactive molecules, whose production is triggered by tobacco smoke. Author information: (1)Center for Sepsis Control and Care, Jena University Hospital, 07747, Jena, Germany. 3,149 Followers, 89 Following, 94 Posts - See Instagram photos and videos from UNISPORT Jena (@unisport_jena) We propose... Genetic aberrations are required for the progression of HPV-induced cervical precancers. (2009). karolin.heinze@med.uni-jena.de. These authors contributed equally to this work.Correspondence: Bachstrasse 18, 07743 Jena, Germany. In the presence of ECs a lipopolysaccharide (LPS)-stimulus led to a significant increase... Liver dysfunction is an early event in sepsis-related multi-organ failure. E-mail address: sandy.mosig@mti.uni‐jena.de. Particle Formulation Group (PFG) Jena Center for Soft Matter (JCSM) Friedrich-Schiller-Universität Jena Philosophenweg 7 07743 Jena Telefon: +49 3641 9 48 599 University students and faculty, institute members, and independent researchers, Technology or product developers, R&D specialists, and government or NGO employees in scientific roles, Health care professionals, including clinical researchers, Journalists, citizen scientists, or anyone interested in reading and discovering research. Expression of NPC1 and ABCA1 in monocytes of FH patients and of healthy control individuals. Despite intensive research the physiological role and molecular mechanisms of action of the lipophilic antioxidant α-tocopherol (α-TOH(4)) are still poorly understood. non-parenchymal cells closely reflecting tissue archit... Background A: legend of array index. Learn more. The centers of the boxes represent the median of the genes, upper and lower ends of the boxes represent the 75th and 25th quartiles, respectively. Mosig, S., et al. The targeted drug delivery to the central nervous system represents one of the major challenges in pharmaceutical formulations since it is strictly limited through the highly selective blood-brain barrier (BBB). We show that VEGF lead... With UC2 (You-See-Too) we present an inexpensive 3D-printed microscopy toolbox. Kai Papenfort. Figure 4A–D in this file shows increased expression of CD36 and CD91/Lrp1 on monocytes of FH patients. The new fluorescent mega Stokes dye (peak excitati... Polymer-based nanoparticles are promising drug delivery systems allowing the development of new drug and treatment strategies with reduced side effects. Infections with SARS-CoV-2 lead to mild to severe coronavirus disease-19 (COVID-19) with systemic symptoms. Sorry, you need to be a researcher to join ResearchGate. Institute of Biochemistry II University Hospital Jena Nonnenplan 2-4 07743 Jena Phone: +49 3641 9 390 910 Fax: +49 3641 9 396 402 alexander.mosig@med.uni-jena.de The most promising combination of markers to predict a patient’s outcome was CaMKIINα and RUNX3. The Faculties of Friedrich Schiller University Jena The University is organised into ten Faculties: Important factors influencing the behavior of nanoparticles in vivo cannot be simulated in scree... Cell-based assays and organ-like substrates gather increasing attention due to their potentials in diagnostic and drug development. qRT-PCR analysis of SREBP gene expression of FH patients receiving statin medication and FH patients without statin therapy. This corrects the article DOI: 10.1038/srep21868. The VBM toolboxes are a collection of extensions to the segmentation algorithm of SPM2, SPM5, and SPM8 (Wellcome Department of Cognitive Neurology) to provide voxel-based morphometry (VBM). However, antibiotic treatment can disturb the bacterial microbiota, facilitating fungal overgrowth and favoring pathogenicity. Image: Jan-Peter Kasper (University of Jena) Funding your research at ACP. Tumour-associated macrophages mainly comprise immunosuppressive M2 phenotypes that promote tumour progression besides anti-tumoural M1 subsets. joachim [dot] denzler [at] uni-jena [dot] de: Phone: +49 3641 946420: Consultation hour: Monday, 2-3 pm (during the lecture periods) Postal Address. Cell type-specific delivery of short interfering RNAs by dye-functionalised theranostic nanoparticles. Learn more. 3, Room 5.11, 5th floor Phone: + 49 (0) 3641 / 9-43230 Fax: + 49 (0) 3641 / 9-43232 Email: Anja.Ladig@uni-jena.de Office hours Although the viral infection originates in the respiratory system, it is unclear how the virus can overcome the alveolar barrier, which is observed in severe COVID-19 disease courses. Pneumonia is the leading cause of hospitalization worldwide. Analyses of gene and protein expression by qRT-PCR and Western Blot reveal down-regulation of members of the SREBP-pathway. Author information: (1)Molecular Hemostaseology, Friedrich-Schiller-University of Jena, Jena, Germany. CD91/Lrp1 is not involved in nLDL uptake. Molecular Hemostaseology, Friedrich‐Schiller‐University of Jena, Jena, Germany. This also applies to the exams. Lehrstuhl für Digitale Bildverarbeitung Friedrich-Schiller-Universität Jena 07737 Jena, Germany . In this context, Staphylococcus... Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor family playing pivotal roles in regulating glucose and lipid metabolism as well as inflammation. University of Jena Teaching Research Team Faculty Back Team Microeconomics Team Team Information about our team. It is able to infect and replicate within Kupffer cells, specialized tissue macrophages of the liver, and to modulate the immune response upon infection to its own advantage. Search for more papers by this author. Correspondence: Dr. Alexander S. Mosig (alexander.mosig@med.uni-jena.de), Institute of Biochemistry II, Jena University Hospital, Am Nonnenplan 2–4, 07743 Jena, Germany.Search for more papers by this author. Monika Keilich Friedrich Schiller University Jena Leutragraben 1 07743 Jena. You just pay a small fee for courses in the language centre or sports centre, which are not on the curriculum. Attractive, creative projects and internships at any time. Taurolidine has been used for peritonitis, oncological and catheter-lock treatment because of its anti-inflammatory properties. Press, A. T., et al. Within the liver, non-parenchymal cells (NPCs) are critically involved in the regulation of hepatocyte polarization and maintenance of metabolic function. Beyond the virulence of the virus itself, epidemiological data suggest that bacterial co-infections are the major cause of increased mortality. Please use the string “Application for PD position – SURNAME NAME” in the email subject and use the PDF format for all your files. Gröger M(1), Dinger J(2), Kiehntopf M(3), Peters FT(2), Rauen U(4), Mosig AS(1). Cigarette smoke components have a proven negative influence on human health. Last update: June 2, 2020 Due to the Corona pandemic, the courses in the current summer term 2020 and also in the upcoming winter term 2020/2021 will be online courses. Quality control of microarry raw data. We sought to examine effects of a high‐saturated‐fat (HF) diet on ACE within the NUtriGenomic A... Abstract Near infrared spectroscopy (NIRS) is a rapid and non-destructive method for compositional analysis of biological material. Histogram bars indicate the mean ± SD (* p < 0.05, ** p < 0.01). (2)Institute of Forensic Medicine, Jena University Hospital, 07747, Jena, Germany. Wallert, M., et al. Histogram bars indicate the mean ± SD. Learn more. (2015). International Organizations and Crisis Management - IOCM in short - is the masters degree in political science of the Chair for International Relations at the Friedrich-Schiller-University Jena. Genes and proteins of the SREBP pathway are down-regulated in monocytes of FH patients. The data provided show that NPC1 as well as ABCA1 expression is deceased in FH monocytes. The Friedrich Schiller University on social media: Research Group Leader Biochip-based organ models. nuttawan.sawangboon@uni-jena.de +49 3641 9-48516 Room K018 Fraunhoferstraße 6 07743 Jena Professorship of Bioactive Glasses Site plan Image: Delia Brauer. Author information: (1)Department of Gynecology, Jena University Hospital-Friedrich Schiller University Jena, 07747 Jena, Germany. Center for Sepsis Control and Care, Jena University Hospital, 07747 Jena, Germany. Different functions of monocyte subsets in familial hypercholesterolemia: potential function of DC14+ CD16+ monocytes in detoxification of oxidized LDL. The data provides show an increased lipid content in monocytes of FH patients compared to healthy individuals. A prototypic substance is the anti-tuberculosis agent INH, which is metabolized into N-acety... Organs-on-a-Chip werden immer häufiger als ethisch vertretbare Alternative zu Tierversuchen genannt und wurden kürzlich vom World Economic Forum zu den “Top 10 Emerging Technologies in 2016“ gezählt. Email: falk.eilenberger@uni-jena.de Phone: +49 3641 9 47990 The Junior Research Group "Optics in 2D-Materials" is dedicated to the understanding of light-matter-interaction in atomically thin layers of nanomaterials, to the tailoring of their optical response, and to … Mit dem Benutzen der Webseite erklären Sie sich der Nutzung von Cookies einverstanden. ); : 2592, Gene expression in the detection of autologous blood transfusion in sports - A pilot study, Different functions of monocyte subsets in familial hypercholesterolemia: Potential function of CD14+CD16+ monocytes in detoxification of oxidized LDL, Monocytes of patients with familial hypercholesterolemia show alterations in cholesterol metabolism, Glucose-dependent insulinotropic polypeptide (GIP) modulates inflammatory markers and regulates proliferation in subcutaneous adipose tissue, Gene expression profiles of T lymphocytes are sensitive to the influence of heavy smoking: A pilot study, Exercise affects the gene expression profiles of human white blood cells, Untersuchung von atherosklerotischen Prozessen in zirkulierenden Monozyten und T-Zellen von Patienten mit familiärer Hypercholesterinämie, Effects Of Acute Exercise On Gene Expression Profiles In White Blood Cells, Effects Of Acute Exercise On Gene Expression Profiles In White Blood Cells: 1742 12:15 PM - 12:30 PM, Epigenetics in Macrophage polarisation and Sepsis, Clinic of Gastroenterology, Metabolic Diseases and Internal Medicine Intensive Care (Medical Clinic III), Department of Nutritional, Food and Consumer Sciences. Statin therapy has no effect of SREBP gene expression in monocytes. Long-term overseas dispatch program in Friedrich Schiller University Jena D2 Kaori Machitani Takeda 1. Electronic address: alexander.mosig@med.uni-jena.de. S., et al. There are no tuition fees at the Friedrich Schiller University Jena. Contact email: Ignacio.rubio[at]med.uni-jena.de or Alexander.mosig[at]med.uni-jena.de Description: Research project: TORREG - Role of mTOR-dependent metabolic adaption for macrophage function assessed in a microphysiological model of the liver Delivery&Parcel Address. The toolboxes are named according to the SPM version. In this work, Raman spectroscopic cell imaging approaches and a discrimination between HepG2, nondifferentiated hepatic stem cell line HepaRG, and differentiated hepatocyte‐like HepaRG cells are presented. Long-chain metabolites of vitamin E: A new class of regulatory metabolites modulating atherogenic processes? alexander.mosig@med.uni-jena.de. Aim was to identify methylated genes with functional involvement in cisplatin-resistance development of epithelial ovarian cancer (EOC). 17 6 Center for Electron Microscopy, Jena University Hospital, Ziegelmuehlenweg 1, D-07743 Jena, Germany 18 19 20 * Correspondence: Dr. Stefanie Deinhardt-Emmer 21 Institute of Medical Microbiology, 22 Jena University Hospital, 23 Am Klinikum 1, 24 D-07747 Jena, Germany 25 26 Email: stefanie.deinhardt-emmer@med.uni-jena.de E‐mail: sandy.mosig@mti.uni‐jena.de Search for more papers by this author A prerequisite for clonal expansion of cancer cells is unlimited proliferative capacity. mRNA expression of A: CD36 and B: LRP1 is elevated in monocytes of patients with homozygous or heterozygous FH compared to controls. ABCA1 expression is further decreased during monocyte to macrophage differentiation of FH monocytes compared to monocytes of healthy individuals. Here, we established a new microfluidically supported, biochip-based model of the brain endothelial barrier in c... Fractalkine (FKN, CX3CL1) is a regulator of leukocyte recruitment and adhesion, and controls leukocyte migration on endothelial cells (ECs). Henceforth, it is possible to proceed the studies or to start the studies without being physically in Jena. In general, surfactant protein-A (SP-A) represents a first line of immune defense. Dr. Mosig was a researcher I got to know Center for Sepsis Control and Care (CSCC), French Institute of Health and Medical Research, Competence Cluster for Nutrition and Cardiovascular Health (nutriCARD), Center for Infectious Disease and Infection Control & Deparment of Anesthesiology and Intensive Care Medicine, Anesthesiology and Intensive Care Medicine, Rapid Target Binding and Cargo Release of Activatable Liposomes Bearing HER2 and FAP Single-Chain Antibody Fragments Reveal Potentials for Image-Guided Delivery to Tumors, SARS-CoV-2 causes severe alveolar inflammation and barrier dysfunction, Staphylococcus aureus Lung Infection Results in Down-Regulation of Surfactant Protein-A Mainly Caused by Pro-Inflammatory Macrophages, VEGF Triggers Transient Induction of Autophagy in Endothelial Cells via AMPKα1, UC2 - A Versatile and Customizable low-cost 3D-printed Optical Open-Standard for microscopic imaging, Co-infection with Staphylococcus aureus after primary influenza virus infection leads to damage of the endothelium in a human alveolus-on-a-chip model, The PPARγ antagonist 2-chloro-5-nitro-N-phenylbenzamide (GW9662) triggers PLIN2 expression via PPARδ and induces lipogenesis and triglyceride accumulation in human THP-1 macrophages, The vitamin E derivative α-amplexichromanol as anti-inflammatory lead inspired from traditional African medicine, Keeping Candida commensal – How lactobacilli antagonize pathogenicity of Candida albicans in an in vitro gut model, A three-dimensional immunocompetent intestine-on-chip model as in vitro platform for functional and microbial interaction studies, CAAP48, a New Sepsis Biomarker, Induces Hepatic Dysfunction in an in vitro Liver-on-Chip Model, UC2 – A 3D-printed General-Purpose Optical Toolbox for Microscopic Imaging, Candida albicans β-Glucan Differentiates Human Monocytes Into a Specific Subset of Macrophages, Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase, Raman spectroscopic investigation of the human liver stem cell line HepaRG, Microphysiological systems meet hiPSC technology – New tools for disease modeling of liver infections in basic research and drug development, Corrigendum: Monocyte-induced recovery of inflammation-associated hepatocellular dysfunction in a biochip-based human liver model, Functional analyses of RUNX3 and CaMKIINα in ovarian cancer cell lines reveal tumor-suppressive functions for CaMKIINα and dichotomous roles for RUNX3 transcript variants, Short-term treatment with taurolidine is associated with liver injury, Preservation of Cell Structure, Metabolism, and Biotransformation Activity of Liver-On-Chip Organ Models by Hypothermic Storage, Thermo-responsive cell culture carrier: Effects on macrophage functionality and detachment efficiency, Tribbles 2 mediates cisplatin sensitivity and DNA damage response in epithelial ovarian cancer, Evaluation of HepaRG cells for the assessment of indirect drug-induced hepatotoxicity using INH as a model substance, Organs-on-a-Chip: Neue Perspektiven in der Medikamentenentwicklung und Personalisierten Medizin, Selective upregulation of TNFα expression in classically-activated human monocyte-derived macrophages (M1) through pharmacological interference with VATPase, Modulation of actin dynamics as potential macrophage subtype-targeting anti-tumour strategy, High‐Saturated‐Fat Diet Increases Circulating Angiotensin‐Converting Enzyme, Which Is Enhanced by the rs4343 Polymorphism Defining Persons at Risk of Nutrient‐Dependent Increases of Blood Pressure, Novel approach for the prediction of cell densities and viability in standardized translucent cell culture biochips with near infrared spectroscopy, Crossing the blood-brain barrier: Glutathione-conjugated poly(ethylene imine) for gene delivery, Organ-on-chip models: new opportunities for biomedical research, An integrative microfluidically supported in vitro model of an endothelial barrier combined with cortical spheroids simulates effects of neuroinflammation in neocortex development, Recruitment of CD16+ monocytes to endothelial cells in response to LPS treatment and concomitant TNF release is regulated by CX3CR1 and interfered by soluble fractalkine, Monocyte-induced recovery of inflammation-associated hepatocellular dysfunction in a biochip-based human liver model, A human macrophage – hepatocyte co-culture model for comparative studies of infection and replication of Francisella tularensis LVS strain and subspecies holarctica and mediasiatica, A new fluorescent dye for cell tracing and mitochondrial imaging in vitro and in vivo, High fat diet induced association of anti-inflammatory phospholipid and CRP levels in human adipose tissue in the NUGAT study, A Microfluidically Perfused Three Dimensional Human Liver Model, Comparison of the uptake of methacrylate-based nanoparticles in static and dynamic in vitro systems as well as in vivo, A biochip-based liver organoid model of human sepsis. Evaluation of epigenetic mechanisms in a septic liver model. (10)Institute of Biochemistry II and Center for Sepsis Control and Care, University Hospital Jena, Jena, Germany. We aim to democratize microscopy, reduce the reproduction crisis and enhance trust into science by making it available to everyone via … Lehrstuhl für Digitale Bildverarbeitung Raum 1220 Ernst-Abbe-Platz 2 However, it remains a challenge to screen for new and effective nanoparticle-based systems in vitro. Only verified researchers can join ResearchGate and send messages to other members. We here report the Address: 1Molecular Hemostaseology, Friedrich-Schiller-University of Jena, Bachstrasse 18, 07743 Jena, Germany, 2Institute of Molecular Cell Here, we describe highly specific nanoparticles, based on near infrared fluorescent polymethine dye-derived targeting moieties coupled to biodegradable polymers. Julia Dinger. The nut seeds of Garcinia kola are traditionally used in African medicine and known for their anti-microbial, anti-oxidative and anti-inflammatory activities. In this study, we analyzed whether influenza A virus (IAV) and/or Staphylococcus aureus (S. aureus) infections affect SP-A express... AMP-activated protein kinase (AMPK) is activated by vascular endothelial growth factor (VEGF) in endothelial cells and it is significantly involved in VEGF-induced angiogenesis. The Functional Photonic Nanostructures junior research group at the Institute of Applied Physics is dedicated to the study of the fundamental optical properties and potential applications of subwavelength … Institut für Biochemie II Universitätsklinikum Jena Nonnenplan 2-4 07743 Jena Telefon: +49 3641 9 390 910 Telefax: +49 3641 9 396 402 alexander.mosig@med.uni-jena.de sandy.mosig@mti.uni-jena.de The study was undertaken to investigate whether the two major monocyte subsets defined by the surface markers CD14(+)CD16(+) and CD14(++)CD16(-) show differences in their responses to hypercholesterolemia.
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